Cimetidine alters pethidine disposition in man.
نویسندگان
چکیده
منابع مشابه
Pethidine | Pethidine Addiction | Pethidine Withdrawal
Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as its hydrochloride salt in tablets, as a syrup, or by intramuscular or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1983 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared to morphine, pethidine was supposed...
متن کاملPethidine | Pethidine Addiction | Pethidine Withdrawal
Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as its hydrochloride salt in tablets, as a syrup, or by intramuscular or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1983 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared to morphine, pethidine was supposed...
متن کاملPethidine | Pethidine Addiction | Pethidine Withdrawal
Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as its hydrochloride salt in tablets, as a syrup, or by intramuscular or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1983 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared to morphine, pethidine was supposed...
متن کاملThe Metabolism of Cimetidine in the Rat, Dog and Man
The metabolism of metiamide (1, Scheme l), the first orally active histamine H2-receptor antagonist, has already been described (Taylor, 1973). Cimetidine (2, Scheme 1) is a new H,-receptor antagonist described by Brimblecombe et al. (1975), in which the thioureido group of metiamide (1) is replaced by a cyanoguanidino group. The present communication reports some initial studies on the metabol...
متن کاملBuprenorphine alters desmethylflunitrazepam disposition and flunitrazepam toxicity in rats.
High-dosage buprenorphine (BUP) consumed concomitantly with benzodiazepines (BZDs) including flunitrazepam (FZ) may cause life-threatening respiratory depression despite a BUP ceiling effect and BZDs' limited effects on ventilation. However, the mechanism of BUP/FZ interaction remains unknown. We hypothesized that BUP may alter the disposition of FZ active metabolites in vivo, contributing to r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1984
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1984.tb02563.x